Isoallolithocholic acid (C09-1140-066)

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid ( HY-10219 ), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation.In VitroIsoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) (20 μM) reduces Th17 cell differentiation by ~50% without affecting RORγt expression. Isoallolithocholic acid does not affect T cell differentiation into Th1 or Th2 cells, the modulatory effect of Isoallolithocholic acid on Tregs is cell-type specific. Isoallolithocholic acid-dependent enhanced expression of FoxP3 requires mitoROS. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIsoallolithocholic acid (0.03%; in diet; 7 days) enhances Treg cells in B6 mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Segmented filamentous bacteria (SFB)-colonized Jax-B6 mice Dosage: 0.03% (w/w) Administration: In diet, 7 days Result: Was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to control diet in combination with 0.3% (w/w) 3-oxolithocholic acid (3-oxoLCA). Reduced the number of CD45.1 + T effector cells.Form:Solid. Specification: ≥98.0% Molecular Formula: C24H40O3 Molecular Weight: 376.57 PubChem CID: 94228 Isomeric SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@H](C4)O)C)C