Isopropylmagnesium chloride lithium chloride complex solution (C15-1307-387)

Application

Reagent for Selective Metalations

Used for:

• Preparation of functionalized acyclic alkenyl magnesium reagents/preparation of 1,2-diketones
• Preparation of cyclic alkenyl and dienyl magnesium reagents
• Preparation of functionalized triazenes/preparation of carbazoles
• Regioselective functionalization of trisubstituted pyridines
• Electrophilic amination for preparation of amines
• Preparation of Grignards reagents in the presence of masked ketones and aldehydes (using readily deprotectable silylated cyanohydrins)
• Preparation of Benzylic Grignards via Sulfur-Magnesium exchange
• Functionalization via I-Mg Exchange of unprotected aromatic and heteroaromatic carboxylic acids
• Functionalization via I-Mg Exchange of unprotected imidazoles
• Pyridyne formation
• Functionalization of cyclopentene derivatives
• Preparation of 2,3-functionalized furans, benzofurans, and thiophenes
• Stereoselective synthesis of substituted cyclopropanes

Reagent used with CH₃MgCl/LiCl to affect magnesium-halogen exchange on unprotected aryl carboxylic acids.

Packaging

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Legal Information

Product of Albemarle US Inc

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Molecular Weight: 145.24. Empirical Formula: C₃H₇Cl₂LiMg. linearFormula: (CH₃)₂CHMgCl · LiCl. reaction suitability: reaction type: Grignard Reaction. Quality Level: 100, 200. concentration: 1.3 . M in THF. density: 0.951 . g/mL . at 25 . °C. SMILES string: [Li]Cl.CC(C)[Mg]Cl. InChI: 1S/C3H7.2ClH.Li.Mg/c1-3-2. . . . /h3H,1-2H3. 2*1H. . /q. . . 2*+1/p-2. InChI key: CWTUREABAILGIK-UHFFFAOYSA-L. Pictograms: GHS02,GHS05,GHS07,GHS08. Signal Word: Danger. Hazard Statements: H225 - H314 - H335 - H336 - H351. Precautionary Statements: P202 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338. Hazard Classifications: Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B. Supp Hazards: EUH014 - EUH019. Storage Class Code: 3 - Flammable liquids. WGK: WGK 3. Flash Point(F): 1.4 °F. Flash Point(C): -17 °C. Personal Protective Equipment: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter.