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JAK3 INHIBITOR II 1PC X 5MG (C15-1660-363)

Catalog No.
C15-1660-363
Mfr. No.
420107-50UG
Mfr. Name
Sigma-Aldrich
Qty/UOM
50
UOM
UG
Price: $554.79
List Price: $616.44

General description A cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties.

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General description

A cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca2+ entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127) in DMSO is also available.

Biochem/physiol Actions

Kd = 15 nM for actin binding

Primary Target
Inducer of actin polymerization and stabilization in vitro

Warning

Toxicity: Harmful (C)

Other Notes

Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem.269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother.32, 1154.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:
51473100
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
420107-50UG
CAS:
102396-24-7

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