JNJ-42041935 (C09-1140-830)

JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylase PHD ; inhibits PHD1, PHD2, and PHD3 with pK i values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively.In VitroJNJ-42041935 is the most potent inhibitor of PHD2 181–417 with a pIC 50 value of 7.0±0.03. JNJ-42041935 also inhibits full-length PHD1, PHD2, and/nPHD3 enzymes (pK i values 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively). MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoJNJ-42041935 is used to compare the effect of selective inhibition of PHD to intermittent, high doses (50 μg/kg i.p.) of an exogenous erythropoietin receptor agonist in an inflammation induced anemia model in rats. JNJ-42041935 (100 μmol/kg, once a day for 14 days) is effective in reversing inflammation induced anemia, whereas erythropoietin has no effect. Administration of JNJ-42041935 (100 μmol/kg p.o.) for 5 consecutive days resulted in a 2-fold increase in reticulocytes, an increase in hemoglobin by 2.3 g/dl, and an increase in the hematocrit of 9%. Two hours after oral administration of 300 μmol/kg JNJ-42041935, the bioluminescence over the peritoneal area is increased by 2.2 ± 0.3-fold relative to luciferase-treated vehicle controls in the mouse . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:pK i : 7.91±0.04 (PHD1), 7.29 ±0.05 (PHD2), 7.65±0.09(PHD3). Specification: 0.99 Molecular Formula: C12H6ClF3N4O3 Molecular Weight: 346.65 PubChem CID: 45102710 Isomeric SMILES: C1=C2C(=CC(=C1Cl)OC(F)(F)F)N=C(N2)N3C=C(C=N3)C(=O)O