JNJ-46281222 is an metabotropic glutamate (mGlu) 2 -selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity ( K d = 1.7 nM) and a high modulatory potency ( pEC 50 = 7.71)In VitroJNJ‐4628122 binds to the selected mGlu2 receptor mutants is significantly decreased by approximately 10‐fold compared with WT, in transfected mGlu2 WT and mutant receptors in CHO‐K1 cells, mutations F643A and N735D are selected. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: CHO‐K1 cells Concentration: Incubation Time: Result: Showed a decreased expression of mGlu2 receptor in mutant cells.Form:SolidIC50& Target:mGluR2 1.7 nM (Kd). Specification: 0.98 Molecular Formula: C23H25F3N4 Molecular Weight: 414.47 PubChem CID: 49822115 Isomeric SMILES: C1CC1CC2=NN=C3N2C=CC(=C3C(F)(F)F)CN4CCC(CC4)C5=CC=CC=C5
- UPC:
- 51171525
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- J647807-50mg
- CAS:
- 1254980-38-5
- Product Size:
- 50mg
