An aminopyridine compound that inhibits JNK1, JNK2, and JNK3 (Kis = 2, 4, and 52 nM, respectively) inhibits the phosphorylation of the JNK substrate c-Jun in HepG2 cells (EC50 = 920 nM).
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An aminopyridine compound that inhibits JNK1, JNK2, and JNK3 (Kis = 2, 4, and 52 nM, respectively); inhibits the phosphorylation of the JNK substrate c-Jun in HepG2 cells (EC50 = 920 nM).
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