KCC2 blocker 1 is an orally active and selective K + -Cl - cotransporter KCC2 blocker with an IC 50 of 1 μM. KCC2 blocker 1 is a benzyl prolinateIn VitroKCC2 blocker 1 (compound 13; 100 μM) inhibits NKCC1 with 35%. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoKCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t 1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL for male Wistar rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats Dosage: 1 mg/kg or 6 mg/kg (Pharmacokinetic Analysis) Administration: IV (1 mg/kg) and PO (6 mg/kg) Result: Had a t 1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL.Form:SolidIC50& Target:IC50: 1 μM (KCC2). Specification: 0.98 Molecular Formula: C22H25NO5S Molecular Weight: 415.5 PubChem CID: 46866400 Isomeric SMILES: CC(=O)N1CCCC1(CC2=CC=C(C=C2)S(=O)(=O)C)C(=O)OCC3=CC=CC=C3
- UPC:
- 51282131
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- K651890-5mg
- CAS:
- 1228439-36-8
- Product Size:
- 5mg
