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kigamicin c

Kigamicin C

Aladdin

Catalog No.
C09-0930-442
Manufacturer No.
K329567-500μg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $377.87
List Price: $419.86

Kigamicin C is a member of the kigamicin antibiotics isolated from|Amycolatopsis|culture broths, with antimicrobial and antiproliferative properties. The kigamicins demonstrate growth inhibition of methicillin-resistant|Staphylococcus

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Kigamicin C is a member of the kigamicin antibiotics isolated from|Amycolatopsis|culture broths, with antimicrobial and antiproliferative properties. The kigamicins demonstrate growth inhibition of methicillin-resistant|Staphylococcus aureus|strains, are active against gram-positive bacteria, and inactive against gram-negative bacteria. Kigamicin C and other kigamicins demonstrate cytotoxicity against PANC-1 pancreatic cancer cells under nutrient starved conditions, requiring a markedly lower concentration (~100-fold) of kigamicin to inhibit growth of PANC-1 cells under nutrient-starved conditions than under nutrient-rich conditions. It is proposed that the kigamicins block the activation of PKB/Akt signaled by PANC-1 cells in response to a nutrient-deprived state, disturbing a potential mechanism of cancer starvation resistance. Extending these observations, Kigamicin D (representing the kigamicin family) is specifically show to suppress an activating phosphorylation of Akt presented by cells in response to a nutrient-starved growth medium. Kigamicin C and the kigamicins (named for kiga, a japanese word for starvation) present a novel intervention upon the resistance to nutrient starvation characteristic of oncogenesis. Specification: ≥97% Molecular Formula: C41H47NO16 Molecular Weight: 809.81 PubChem CID: 312853591 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/K329567-SCI_b07bdf11e44e24d743a470e4e79af9ee.pdf
UPC:
12352005
Condition:
New
Availability:
8-12 weeks
Weight:
0.96 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
K329567-500μg
CAS:
680571-51-1
Product Size:
500μg
Precautionary Statement Codes:
P264


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