KL-2 (C15-1722-316)

Catalog No.: C15-1722-316
Mfr. No.: SML2538-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $246.41

List Price: $273.79

Biochem/physiol Actions Disruptor of SEC (super elongation complex) KL-2 is a disruptor of the super elongation complex (SEC). KL-1 blocks the interactions of positive transcription elongation factorb (P-TEFb) and the SEC-scaffolding protein

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Biochem/physiol Actions

Disruptor of SEC (super elongation complex)

KL-2 is a disruptor of the super elongation complex (SEC). KL-1 blocks the interactions of positive transcription elongation factorb (P-TEFb) and the SEC-scaffolding protein AFF4 resulting in decreased Polymerase II (Pol II) activity and production of Pol II-transcribed genes. KL-2 was shown to cause downregulation of heat shock genes, and was non-toxic and active in an animal model of cancer.

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UPC:: 51112702
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: Yes
MPN:: SML2538-5MG
CAS:: 900308-51-2

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