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kolliphor(r) hs 15

Kolliphor(R) HS 15

Sigma-Aldrich

Catalog No.
C15-1258-836
Manufacturer No.
42966-1KG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
KG
Price: $632.57
List Price: $702.86

Kolliphor ® HS 15, a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents.

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General description

Kolliphor® HS 15, a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).

Kolliphor® HS 15 is an excellent non-ionic solubilizer that finds application in excipient and formulation research.

Application

Kolliphor® HS 15 has been used:

  • in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle force
  • in roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses
  • to dissolve finerenone for oral application in in vivo-studies

Biochem/physiol Actions

Kolliphor® HS 15 is mainly used as a solubilizer in parenteral and oral formulations. It is preferred for in vitro screening and in vivo efficacy studies of compounds. Kolliphor® HS 15 is also used in ophthalmic, macromolecule, suppository, and protein formulations due to its solubilization characteristics and safety profiles. It can form micelles typically ranging from 10-15 nm. Kolliphor® HS 15 can be used to develop micro-emulsion IV formulations.

Features and Benefits

  • Low histamine release for fewer side-effects
  • Offers thermal stability, suitable for heat sterilization      
  • Has lower hemolytic activity than other polyoxyethylene-based surfactants      
  • Allows to formulate poorly soluble APIs in oral and parenteral dosage forms

Other Notes

Kolliphor HS 15 is a non-ionic detergent obtained by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxy stearic acid.

This research-grade product is intended for use in R&D and development only.

Legal Information

Kolliphor is a registered trademark of BASF

Solutol is a registered trademark of BASF SE

UPC:
41116134
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
42966-1KG


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