KP496

KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor .In VivoKP496 significantly inhibits acute (day 7) and chronic (day 21) lung inflammation. KP496 attenuates the number of lymphocytes on day 7 and those of macrophages, neutrophils, and eosinophils on days 7 and 21. KP496 and prednisolone significantly suppress the increase of hydroxyl-L-proline content in the lung. Compare to respective vehicle control group, the inhibition ratio of KP496 and prednisolone for increase of hydroxyl-L-proline content is about 74 and 63%, respectively . The KP496 (100 mg/head) group and prednisolone (10 mg/kg) group exhibit significant inhibition of numbers of infiltrating total cells, eosinophils, monocytes/macrophages, and lymphocytes compare with the control group. Infiltration of all types of cells except neutrophils is decreased in the KP496 (30m g/head) group, though not to significant extents. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:LTD 4 TXA 2 Receptor. Specification: 0.99 Molecular Formula: C31H34ClN3O7S3 Molecular Weight: 692.27 PubChem CID: 11578433 Isomeric SMILES: CC(C)C1=CSC(=N1)COC2=CC=CC(=C2)CN(CCCCNS(=O)(=O)C3=CC=C(C=C3)Cl)S(=O)(=O)C4=CC=CC=C4C(=O)O