KT195 (C005B-312283)

Catalog No.: C005B-312283
Mfr. No.: SML1308-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $890.64

List Price: $989.60

Biochem/physiol Actions KT195 is a potent (IC 50 = 10 nM) and selective inhibitor of α:/β:-hydrolase domain-containing 6 (ABHD6), a serine hydrolase that acts as an alternative hydrolase of the endocannabinoid 2-arachidonoylglycerol

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Description
Specifications

Biochem/physiol Actions

KT195 is a potent (IC₅₀ = 10 nM) and selective inhibitor of α/β-hydrolase domain-containing 6 (ABHD6), a serine hydrolase that acts as an alternative hydrolase of the endocannabinoid 2-arachidonoylglycerol (2-AG). KT195 has negligible activity against other serine hydrolases such as DAGLβ and has been used as a control probe for studies of DAGLβ as well as being a probe on its own to study ABHD6. KT195 treatment of Neuro2A cells caused significant accumulation of 2-AG. KT195 also lowered interleukin-1β (IL-1β) secretion from lipopolysaccharide-treated macrophages suggesting ABHD6 involvement in this activity as well.

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UPC:: 51171984
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: Yes
MPN:: SML1308-25MG
CAS:: 1402612-58-1

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