Kushenol A (C09-1141-467)

Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent . Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC 50 and K i values of 1.1 μM and 0.4 μM, respectively Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase ( IC 50 : 45 μM; K i : 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and agingIn VitroKushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC 50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM. Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC 50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC 50 value of 57.2 μg/ml for BEAS-2B cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: NSCLC cell lines, A549 and NCI-H226 Normal human lung epithelial: BEAS-2B Concentration: 0-60 μg/ml Incubation Time: 24 hours Result: Exhibited considerable cytotoxic effects against NSCLC cells.Form:SolidIC50& Target:IC50: 1.1 μM (tyrosinase),45 μM (alpha-glucosidase). Specification: 0.99 Molecular Formula: C25H28O5 Molecular Weight: 408.49 PubChem CID: 44563121 Isomeric SMILES: CC(=CC[C@H](CC1=C2C(=C(C=C1O)O)C(=O)C[C@H](O2)C3=CC=CC=C3O)C(=C)C)C