Kynurenic acid (C09-0930-891)

Product IntroductionKynurenic acid is a metabolite of tryptophan in mammals via the kynurenine pathway. Studies have observed that Kynurenic acid acts as a ligand to the GPR35 G protein-coupled receptor. The binding of Kynurenic acid to GPR35 has been noted to affect calcium mobilization and inositol phosphatase synthesis and may indicate potential signaling functions by Kynurenic acid via the GPR35 receptor. Additionally reported to be a broad spectrum, excitatory amino acid (EAA) antagonist. Other studies have reported that Kynurenic acid acts as an antagonist to mammalian ionotropic glutamate receptors especially NMDA (N-methyl-D-aspartate receptors).Kynurenic acid is an inhibitor of AChR α7, GluR and GlyR.Product UsageAn antagonist of NMDA and AMPA/kainate receptorsKynurenic acid has been used as a constituent in dissection saline solution for embryonic cerebral cortical cells[7] and human primary astrocytes. It has also been used as a medium supplement for murine intestinal epithelial cell line, MODE-K and induced pluripotent stem cell (iPSC)-derived neurons cells. Specification: 10mM in DMSO Molecular Formula: C10H7NO3 Molecular Weight: 189.17 EC Number: 207-751-5 PubChem CID: 3845 Isomeric SMILES: C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O Beilstein Registry Number: 147451 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/K424259-SCI_fa439de4c9412d715f641e34f1dd5556.pdf