L-755,507 (C09-0933-911)

Product description：L755507 is a derivative of 4-acylaminobenzenesulfonamide.Application：L755507 has been shown to enhance CRISPR genome editing efficiency. Biochemical mechanism:L755507 is a potent β3-adrenergic receptor partial agonist with an EC50 value of 0.43 nM for β3 receptors with over 440-fold selectivity for β3 compared to β1 and β2-adrenergic receptor binding. L755507 has been shown to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs), increasing the efficiency of GFP insertion by 3-fold compared to control cells.L755507 is found to stimulate the breakdown of lipids in human adipose tissues. L755507 also promotes urinary bladder relaxation.L755507 is a potent β3-adrenergic receptor partial agonist. Specification: ≥98%(HPLC) Molecular Formula: C30H40N4O6S Molecular Weight: 584.73 PubChem CID: 9829836 Isomeric SMILES: CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNC[C@@H](COC3=CC=C(C=C3)O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/L288431-SCI_47a9610135d1b15e2d8e2126c6f6c477.pdf