L-826266 (C09-1142-614)

L-826266 is a selective and competitive EP3 receptor antagonist. L-826266 can be used for convulsive disorders researchIn VitroIn adult rat hippocampal slices, L-826266 (1 μM) prevents the PGE2-induced decrease of Na+,K+-ATPase activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoL-826266 (0.01-1 nmol/site; i.c.v.; once) delays seizures, and increases the latency for clonic and generalized tonic-clonic seizures induced by PTZ . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult male Wistar rats (250-300 g) injected with Pentylenetetrazol (PTZ) Dosage: 0.01 nmol/site, 0.1 nmol/site or 1 nmol/site Administration: i.c.v.; once Result: Increased the latency for clonic and generalized tonic-clonic seizures induced by PTZ.Form:SolidIC50& Target:EP3. Specification: 0.98 Molecular Formula: C27H21BrClNO4S Molecular Weight: 570.88 PubChem CID: 9808643 Isomeric SMILES: COC1=C(C=C(C=C1)Br)S(=O)(=O)NC(=O)/C=C/C2=C(C=CC(=C2)Cl)CC3=CC4=CC=CC=C4C=C3