General description
Modified amino acids are inhouse manufactured amino acid derivatives with specific properties enabling the intensification of cell culture processes.
Together with the companion product Phospho-L-Tyrosine disodium Salt disodium salt, the new modified amino acid S-Sulfocysteine sodium salt can be used as replacement for cysteine to generate highly concentrated, neutral pH feeds. Both modified amino acids eliminate the need for alkaline feeds, which are normally applied to ensure solubility and stability of the unmodified amino acids tyrosine and cysteine.
Our SAFC® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.
M-Clarity Program
As part of our EMPROVE® Program, our raw materials are offered with EMPROVE® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.
Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
Features and Benefits
- Reduced complexity in fed-batch process
- High concentrations of modified cysteine in main feeds at neutral pH
- Prevention of caustic shocks in the bioreactor due to high pH feeds
- More convenient preparation process with less contamination risks
- Reduction of recombinant protein fragmentation and decrease in trisulfide bond content
- Higher feed stability at room temperature
Linkage
Webinar
Title: Simplification of Fed-Batch Processes Using Modified Amino Acids
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 12352209
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 1371165000
- CAS:
- 150465-29-5
