Life Science

A proapoptoic compound with selectivity for cancer cells induces apoptosis in vitro in various cancer cell lines (IC50 = 0.89-2.69 &microM).

Both inhibits and inactivates, at 100 &microM, certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2).

Both inhibits and inactivates, at 100 &microM, certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2).

Both inhibits and inactivates, at 100 &microM, certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2).

Fluprostenol is a well-studied, potent analog of PGF2&alpha acting primarily through the FP receptor. &beta-Oxidation of fluprostenol yields 2,3-dinor fluprostenol.

Fluprostenol is a well-studied, potent analog of PGF2&alpha acting primarily through the FP receptor. &beta-Oxidation of fluprostenol yields 2,3-dinor fluprostenol.

Fluprostenol is a well-studied, potent analog of PGF2&alpha acting primarily through the FP receptor. &beta-Oxidation of fluprostenol yields 2,3-dinor fluprostenol.

PGE1 is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology. The metabolism of PGE1 is

PGE1 is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology. The metabolism of PGE1 is

PGE1 is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology. The metabolism of PGE1 is

TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.

TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.