Life Science

An endogenous agonist for LXR&alpha (EC₅₀ = 325 nM) that can induce the expression of the ABCA1 reverse cholesterol transporter to inhibit the overall absorption of cholesterol used as a substrate to monitor cholesterol transport or as

An analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis inhibits human keratinocyte proliferation and is beneficial in treating psoriasis blocks the proliferation while inducing

An analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis inhibits human keratinocyte proliferation and is beneficial in treating psoriasis blocks the proliferation while inducing

An analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis inhibits human keratinocyte proliferation and is beneficial in treating psoriasis blocks the proliferation while inducing

A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXR&alpha and LXR&beta nuclear receptors with slightly reduced potency (EC50 = 7 and 4 &muM, respectively) compared to the natural isomer (EC50 = 4 and 3 &muM,

A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXR&alpha and LXR&beta nuclear receptors with slightly reduced potency (EC50 = 7 and 4 &muM, respectively) compared to the natural isomer (EC50 = 4 and 3 &muM,

A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXR&alpha and LXR&beta nuclear receptors with slightly reduced potency (EC50 = 7 and 4 &muM, respectively) compared to the natural isomer (EC50 = 4 and 3 &muM,

A side-chain substituted oxysterol that has important roles in cholesterol homeostasis potently activates LXR&alpha and LXR&beta nuclear receptors (EC50 = 4 and 3 &muM, respectively), causing upregulation of cholesterol-lowering genes.

A side-chain substituted oxysterol that has important roles in cholesterol homeostasis potently activates LXR&alpha and LXR&beta nuclear receptors (EC50 = 4 and 3 &muM, respectively), causing upregulation of cholesterol-lowering genes.

A side-chain substituted oxysterol that has important roles in cholesterol homeostasis potently activates LXR&alpha and LXR&beta nuclear receptors (EC50 = 4 and 3 &muM, respectively), causing upregulation of cholesterol-lowering genes.

An immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic

An immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic