Life Science

A-66 is a potent, selective inhibitor of the PI3K isoform p110&alpha (IC₅₀ = 32 nM in a cell-free assay). It displays over 100-fold selectivity for p110&alpha over other isoforms.

A-66 is a potent, selective inhibitor of the PI3K isoform p110&alpha (IC₅₀ = 32 nM in a cell-free assay). It displays over 100-fold selectivity for p110&alpha over other isoforms.

An inhibitor of ALK5, ALK4, and ALK7 (IC₅₀s = 12, 45, and 7.5 nM, respectively) blocks the phosphorylation of Smad2/3 and inhibits TGF-&beta-induced epithelial-to-mesenchymal transition used to reprogram fibroblasts into alternative

An inhibitor of ALK5, ALK4, and ALK7 (IC₅₀s = 12, 45, and 7.5 nM, respectively) blocks the phosphorylation of Smad2/3 and inhibits TGF-&beta-induced epithelial-to-mesenchymal transition used to reprogram fibroblasts into alternative

An inhibitor of ALK5, ALK4, and ALK7 (IC₅₀s = 12, 45, and 7.5 nM, respectively) blocks the phosphorylation of Smad2/3 and inhibits TGF-&beta-induced epithelial-to-mesenchymal transition used to reprogram fibroblasts into alternative

An inhibitor of ALK5, ALK4, and ALK7 (IC₅₀s = 12, 45, and 7.5 nM, respectively) blocks the phosphorylation of Smad2/3 and inhibits TGF-&beta-induced epithelial-to-mesenchymal transition used to reprogram fibroblasts into alternative

An enzyme-activated, irreversible inhibitor of the arginine decarboxylases of E. coli (Ki = 800 &microM), P.

An enzyme-activated, irreversible inhibitor of the arginine decarboxylases of E. coli (Ki = 800 &microM), P.

An enzyme-activated, irreversible inhibitor of the arginine decarboxylases of E. coli (Ki = 800 &microM), P.

An enzyme-activated, irreversible inhibitor of the arginine decarboxylases of E. coli (Ki = 800 &microM), P.

A selective inhibitor of SUV420H1 and SUV420H2 (IC₅₀s = 25 and 144 nM, respectively) that inhibits the di- and trimethylation of H4K20me in multiple cell lines.

A selective inhibitor of SUV420H1 and SUV420H2 (IC₅₀s = 25 and 144 nM, respectively) that inhibits the di- and trimethylation of H4K20me in multiple cell lines.