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16499-1A pan Akt inhibitor (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation
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16499-5A pan Akt inhibitor (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation
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16499-500A pan Akt inhibitor (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation
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15305-1A natural (ADEP) antibiotic that constitutively activates the bacterial protease ClpP, resulting in uncontrolled proteolysis, inhibition of bacterial cell division, and, ultimately, cell death preferentially targets Gram-positive bacteria.
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15305-5A natural (ADEP) antibiotic that constitutively activates the bacterial protease ClpP, resulting in uncontrolled proteolysis, inhibition of bacterial cell division, and, ultimately, cell death preferentially targets Gram-positive bacteria.
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17090-2.5A natural acyldepsipeptide that is effective against Gram-positive bacteria, including penicillin-resistant S. aureus is also effective against many strains of anaerobic bacteria.
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17090-500A natural acyldepsipeptide that is effective against Gram-positive bacteria, including penicillin-resistant S. aureus is also effective against many strains of anaerobic bacteria.
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17358-1A selective &alpha1A-adrenergic receptor agonist that is at least 35-fold more potent at &alpha1A receptor sites than at &alpha1B or &alpha1D increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro with
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17358-10A selective &alpha1A-adrenergic receptor agonist that is at least 35-fold more potent at &alpha1A receptor sites than at &alpha1B or &alpha1D increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro with
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17358-5A selective &alpha1A-adrenergic receptor agonist that is at least 35-fold more potent at &alpha1A receptor sites than at &alpha1B or &alpha1D increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro with
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18715-1An orally available, reversible inhibitor of Akt (Ki = 11 nM for Akt1) also inhibits PKA and Cdk2 with IC<sub>50</sub> values of 16 and 46 nM, respectively reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor
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18715-10An orally available, reversible inhibitor of Akt (Ki = 11 nM for Akt1) also inhibits PKA and Cdk2 with IC<sub>50</sub> values of 16 and 46 nM, respectively reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor