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18715-5An orally available, reversible inhibitor of Akt (Ki = 11 nM for Akt1) also inhibits PKA and Cdk2 with IC<sub>50</sub> values of 16 and 46 nM, respectively reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor
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18715-500An orally available, reversible inhibitor of Akt (Ki = 11 nM for Akt1) also inhibits PKA and Cdk2 with IC<sub>50</sub> values of 16 and 46 nM, respectively reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor
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16076-10A potent cell-permeable antagonist of calmodulin that inhibits Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7 (IC<sub>50</sub> = 3.2 and 26 µM, respectively).
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16076-25A potent cell-permeable antagonist of calmodulin that inhibits Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7 (IC<sub>50</sub> = 3.2 and 26 µM, respectively).
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16076-5A potent cell-permeable antagonist of calmodulin that inhibits Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7 (IC<sub>50</sub> = 3.2 and 26 µM, respectively).
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11900-10A small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172.
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11900-5A small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172.
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11900-50A small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172.
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18396-1A-77-01 is a potent inhibitor of the TGF-&beta1 receptor ALK5 (IC<sub>50</sub> = 25 nM). It has no effects on BMP-regulated transcriptional activity or MAPK pathways.
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18396-10A-77-01 is a potent inhibitor of the TGF-&beta1 receptor ALK5 (IC<sub>50</sub> = 25 nM). It has no effects on BMP-regulated transcriptional activity or MAPK pathways.
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18396-25A-77-01 is a potent inhibitor of the TGF-&beta1 receptor ALK5 (IC<sub>50</sub> = 25 nM). It has no effects on BMP-regulated transcriptional activity or MAPK pathways.
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18396-5A-77-01 is a potent inhibitor of the TGF-&beta1 receptor ALK5 (IC<sub>50</sub> = 25 nM). It has no effects on BMP-regulated transcriptional activity or MAPK pathways.