Life Science

Activation-Inducible TNF-Related Ligand (AITRL) , also known as Glucocorticoid-Induced TNF-Related Ligand (GITRL), belongs to the tumor necrosis factor superfamily (TNFSF). AITRL is a Type II single transmembrane protein and shares low conservation

Activation-Inducible TNF-Related Ligand (AITRL) , also known as Glucocorticoid-Induced TNF-Related Ligand (GITRL), belongs to the tumor necrosis factor superfamily (TNFSF). AITRL is a Type II single transmembrane protein and shares low conservation

A cell- and brain-permeable inhibitor of SIRT2 (IC₅₀ = 15.5 &muM) dimishes neuronal cell death induced by mutant huntingtin fragment in culture down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol

A cell- and brain-permeable inhibitor of SIRT2 (IC₅₀ = 15.5 &muM) dimishes neuronal cell death induced by mutant huntingtin fragment in culture down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol

A cell- and brain-permeable inhibitor of SIRT2 (IC₅₀ = 15.5 &muM) dimishes neuronal cell death induced by mutant huntingtin fragment in culture down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol

A cell- and brain-permeable inhibitor of SIRT2 (IC₅₀ = 15.5 &muM) dimishes neuronal cell death induced by mutant huntingtin fragment in culture down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol

A potent, allosteric inhibitor of Akt1 and Akt2 (IC₅₀ = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC₅₀ = 2.2 &microM) cell permeable, blocking insulin regulation of FOXO1 activity at 1 &microM

A potent, allosteric inhibitor of Akt1 and Akt2 (IC₅₀ = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC₅₀ = 2.2 &microM) cell permeable, blocking insulin regulation of FOXO1 activity at 1 &microM

A potent, allosteric inhibitor of Akt1 and Akt2 (IC₅₀ = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC₅₀ = 2.2 &microM) cell permeable, blocking insulin regulation of FOXO1 activity at 1 &microM

A potent, allosteric inhibitor of Akt1 and Akt2 (IC₅₀ = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC₅₀ = 2.2 &microM) cell permeable, blocking insulin regulation of FOXO1 activity at 1 &microM

A cell permeable phenoxazine derivative that suppresses IGF-1-stimulated phosphorylation of Akt with an IC₅₀ value of 1-2 &muM inhibits the growth of Rh1, Rh18, and Rh30 cells with IC₅₀ values of 2-5 &muM.

A cell permeable phenoxazine derivative that suppresses IGF-1-stimulated phosphorylation of Akt with an IC₅₀ value of 1-2 &muM inhibits the growth of Rh1, Rh18, and Rh30 cells with IC₅₀ values of 2-5 &muM.