Life Science

A novel CB1 selective neutral antagonist with low CNS penetration (Ki = 1.7 and 523 nM for CB1 and CB2, respectively) reduces food intake, food-reinforced behavior and weight gain improves metabolic profiles of mice with diet-induced obesity.

A retinoic acid receptor agonist that is selective for RAR&alpha (Kd = 62 nM AC50 = 1.46 nM) compared to RAR&beta (Kd = 280 nM AC50 = 6.

A retinoic acid receptor agonist that is selective for RAR&alpha (Kd = 62 nM AC50 = 1.46 nM) compared to RAR&beta (Kd = 280 nM AC50 = 6.

A retinoic acid receptor agonist that is selective for RAR&alpha (Kd = 62 nM AC50 = 1.46 nM) compared to RAR&beta (Kd = 280 nM AC50 = 6.

A retinoic acid receptor agonist that is selective for RAR&alpha (Kd = 62 nM AC50 = 1.46 nM) compared to RAR&beta (Kd = 280 nM AC50 = 6.

A slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of AP-A (glutamyl AP IC₅₀ = 0.54 &microg/ml) but not of AP-B (arginine AP) also inhibits AP-N (AP-M, alanyl AP Ki = 20-200 nM),

A slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of AP-A (glutamyl AP IC₅₀ = 0.54 &microg/ml) but not of AP-B (arginine AP) also inhibits AP-N (AP-M, alanyl AP Ki = 20-200 nM),

A slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of AP-A (glutamyl AP IC₅₀ = 0.54 &microg/ml) but not of AP-B (arginine AP) also inhibits AP-N (AP-M, alanyl AP Ki = 20-200 nM),

A slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of AP-A (glutamyl AP IC₅₀ = 0.54 &microg/ml) but not of AP-B (arginine AP) also inhibits AP-N (AP-M, alanyl AP Ki = 20-200 nM),

AMC-AA is one of several fatty acid amides which can be used to measure FAAH activity. Exposure of AMC-AA to FAAH results in the release of the fluorescent aminomethyl coumarin that absorbs at 360 nm and emits at 465 nm, allowing for fast and

AMC-AA is one of several fatty acid amides which can be used to measure FAAH activity. Exposure of AMC-AA to FAAH results in the release of the fluorescent aminomethyl coumarin that absorbs at 360 nm and emits at 465 nm, allowing for fast and

AMC-AA is one of several fatty acid amides which can be used to measure FAAH activity. Exposure of AMC-AA to FAAH results in the release of the fluorescent aminomethyl coumarin that absorbs at 360 nm and emits at 465 nm, allowing for fast and