Life Science

A class III antiarrhythmic agent inhibits KCNH2 with an IC₅₀ value of 1 &microM also inhibits CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

A class III antiarrhythmic agent inhibits KCNH2 with an IC₅₀ value of 1 &microM also inhibits CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

A class III antiarrhythmic agent inhibits KCNH2 with an IC₅₀ value of 1 &microM also inhibits CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

A potent antagonist of the dopamine receptors D2 and D3 (Ki = 2.8 and 3.2 nM, respectively, for the human receptors) also shown to be a potent antagonist of the serotonin receptors 5-HT2B and 5-HT7 (Ki = 13, 11.5 nM, respectively).

A potent antagonist of the dopamine receptors D2 and D3 (Ki = 2.8 and 3.2 nM, respectively, for the human receptors) also shown to be a potent antagonist of the serotonin receptors 5-HT2B and 5-HT7 (Ki = 13, 11.5 nM, respectively).

A potent antagonist of the dopamine receptors D2 and D3 (Ki = 2.8 and 3.2 nM, respectively, for the human receptors) also shown to be a potent antagonist of the serotonin receptors 5-HT2B and 5-HT7 (Ki = 13, 11.5 nM, respectively).

A potent antagonist of the dopamine receptors D2 and D3 (Ki = 2.8 and 3.2 nM, respectively, for the human receptors) also shown to be a potent antagonist of the serotonin receptors 5-HT2B and 5-HT7 (Ki = 13, 11.5 nM, respectively).

A first generation tricyclic antidepressant blocks the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM, respectively) inhibits 5-HT2A receptor (Ki =20 nM) antagonizes histamine H1, muscarinic acetylcholine, and &alpha1-adrenergic

A first generation tricyclic antidepressant blocks the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM, respectively) inhibits 5-HT2A receptor (Ki =20 nM) antagonizes histamine H1, muscarinic acetylcholine, and &alpha1-adrenergic

A first generation tricyclic antidepressant blocks the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM, respectively) inhibits 5-HT2A receptor (Ki =20 nM) antagonizes histamine H1, muscarinic acetylcholine, and &alpha1-adrenergic

An anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers, commonly used as a 5% topical oral paste associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at

An anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers, commonly used as a 5% topical oral paste associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at