Life Science

A control compound for AP39.

An orally bioavailable inhibitor of ALK (IC₅₀ &lt 100 nM in Ba/F3 cells) a pan-ALK inhibitor that also inhibits several ALK mutants that confer resistance to other ALK inhibitors.

An orally bioavailable inhibitor of ALK (IC₅₀ &lt 100 nM in Ba/F3 cells) a pan-ALK inhibitor that also inhibits several ALK mutants that confer resistance to other ALK inhibitors.

An orally bioavailable inhibitor of ALK (IC₅₀ &lt 100 nM in Ba/F3 cells) a pan-ALK inhibitor that also inhibits several ALK mutants that confer resistance to other ALK inhibitors.

An orally bioavailable inhibitor of ALK (IC₅₀ &lt 100 nM in Ba/F3 cells) a pan-ALK inhibitor that also inhibits several ALK mutants that confer resistance to other ALK inhibitors.

A compound used to increase the levels of H₂S within mitochondria stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM

A compound used to increase the levels of H₂S within mitochondria stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM

A compound used to increase the levels of H₂S within mitochondria stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM

A compound used to increase the levels of H₂S within mitochondria stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM

A potent, selective PAF receptor antagonist (Ki = 9.9 nM at human PAF receptors) displays anti-inflammatory, antiangiogenic, and anticancer activity.

A potent, selective PAF receptor antagonist (Ki = 9.9 nM at human PAF receptors) displays anti-inflammatory, antiangiogenic, and anticancer activity.

A potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3 (IC₅₀ values are 0.06-0.4, 1-12, and 1-13 nM, respectively) ineffective against SK4 at 1 &microM.