Life Science

Promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation induces apoptosis in leukemia cells (IC50 = 4-9 &muM)

Promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation induces apoptosis in leukemia cells (IC50 = 4-9 &muM)

This product is used to measure apoptosis in vitro.

An inhibitor of Hsp70 (65% inhibition at 200 &microM) that acts by blocking its ATPase activity induces apoptosis in cancer cells (IC₅₀ = 5-7 &microM) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without

An inhibitor of Hsp70 (65% inhibition at 200 &microM) that acts by blocking its ATPase activity induces apoptosis in cancer cells (IC₅₀ = 5-7 &microM) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without

An inhibitor of Hsp70 (65% inhibition at 200 &microM) that acts by blocking its ATPase activity induces apoptosis in cancer cells (IC₅₀ = 5-7 &microM) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without

An inhibitor of Hsp70 (65% inhibition at 200 &microM) that acts by blocking its ATPase activity induces apoptosis in cancer cells (IC₅₀ = 5-7 &microM) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without

An orally active inhibitor of PDE4 with an IC₅₀ value of 74 nM when tested in U937 cell lysates with 1 mM cAMP decreases epidermal thickness in a mouse model of psoriasis, reduces both TNF-&alpha and MMP-3 production in gut cells from

An orally active inhibitor of PDE4 with an IC₅₀ value of 74 nM when tested in U937 cell lysates with 1 mM cAMP decreases epidermal thickness in a mouse model of psoriasis, reduces both TNF-&alpha and MMP-3 production in gut cells from

An orally active inhibitor of PDE4 with an IC₅₀ value of 74 nM when tested in U937 cell lysates with 1 mM cAMP decreases epidermal thickness in a mouse model of psoriasis, reduces both TNF-&alpha and MMP-3 production in gut cells from

An orally active inhibitor of PDE4 with an IC₅₀ value of 74 nM when tested in U937 cell lysates with 1 mM cAMP decreases epidermal thickness in a mouse model of psoriasis, reduces both TNF-&alpha and MMP-3 production in gut cells from

An antiemetic compound that selectively antagonizes the human NK1 receptor (Kis = 3 and 454.1 nM for hNK1 and hNK3, respectively IC₅₀ = 0.09 nM for hNK1).