Life Science

AS-604850 is a selective, ATP-competitive inhibitor of PI3K&gamma with IC50 values of 0.25, &gt20, &gt20, and 4.

An orally active inhibitor of PI3-kinase &gamma that suppresses joint inflammation in mouse models of rheumatoid arthritis inhibits human recombinant PI3K&gamma, &alpha, &beta, and &delta in an ATP-competitive manner with IC₅₀

An orally active inhibitor of PI3-kinase &gamma that suppresses joint inflammation in mouse models of rheumatoid arthritis inhibits human recombinant PI3K&gamma, &alpha, &beta, and &delta in an ATP-competitive manner with IC₅₀

An orally active inhibitor of PI3-kinase &gamma that suppresses joint inflammation in mouse models of rheumatoid arthritis inhibits human recombinant PI3K&gamma, &alpha, &beta, and &delta in an ATP-competitive manner with IC₅₀

An orally active inhibitor of PI3-kinase &gamma that suppresses joint inflammation in mouse models of rheumatoid arthritis inhibits human recombinant PI3K&gamma, &alpha, &beta, and &delta in an ATP-competitive manner with IC₅₀

An orally active inhibitor of PI3Kg that suppresses joint inflammation in mouse models of rheumatoid arthritis inhibits human recombinant PI3Kg, a, b, and d in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.

An orally active inhibitor of PI3Kg that suppresses joint inflammation in mouse models of rheumatoid arthritis inhibits human recombinant PI3Kg, a, b, and d in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.

An orally active inhibitor of PI3Kg that suppresses joint inflammation in mouse models of rheumatoid arthritis inhibits human recombinant PI3Kg, a, b, and d in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.

An orally active inhibitor of PI3Kg that suppresses joint inflammation in mouse models of rheumatoid arthritis inhibits human recombinant PI3Kg, a, b, and d in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.

Selectively inhibits MEK1/2 potently inhibits growth and survival of human INA-6 multiple myeloma cells and cytokine-induced osteoclast differentiation (IC50s = 10 and 18.2 nM, respectively) 30 mg/kg reduced tumor growth significantly in mice

Selectively inhibits MEK1/2 potently inhibits growth and survival of human INA-6 multiple myeloma cells and cytokine-induced osteoclast differentiation (IC50s = 10 and 18.2 nM, respectively) 30 mg/kg reduced tumor growth significantly in mice

Selectively inhibits MEK1/2 potently inhibits growth and survival of human INA-6 multiple myeloma cells and cytokine-induced osteoclast differentiation (IC50s = 10 and 18.2 nM, respectively) 30 mg/kg reduced tumor growth significantly in mice