Life Science

Selectively inhibits MEK1/2 potently inhibits growth and survival of human INA-6 multiple myeloma cells and cytokine-induced osteoclast differentiation (IC50s = 10 and 18.2 nM, respectively) 30 mg/kg reduced tumor growth significantly in mice

An isoprenoid antibiotic and antiviral that suppresses PMA-induced invasion in renal carcinoma cells (IC₅₀ = ~10 &microM) by inhibiting the expression of MMP-9 profoundly increases the expression of p53 by increasing protein stability

An isoprenoid antibiotic and antiviral that suppresses PMA-induced invasion in renal carcinoma cells (IC₅₀ = ~10 &microM) by inhibiting the expression of MMP-9 profoundly increases the expression of p53 by increasing protein stability

An ethyl analog of tacrolimus with potent immunosuppressant properties that prevents T-cell proliferation through initial binding to FKBP12, the principal mediator of FK506- and rapamycin-induced immunosuppression inhibits the enzymatic PPIase and

An ethyl analog of tacrolimus with potent immunosuppressant properties that prevents T-cell proliferation through initial binding to FKBP12, the principal mediator of FK506- and rapamycin-induced immunosuppression inhibits the enzymatic PPIase and

An ethyl analog of tacrolimus with potent immunosuppressant properties that prevents T-cell proliferation through initial binding to FKBP12, the principal mediator of FK506- and rapamycin-induced immunosuppression inhibits the enzymatic PPIase and

A natural triterpene which stimulates wound healing induces cell cycle arrest and apoptosis in breast cancer cells (IC50 = 5.9 &microM for MCF-7 cells) blocks angiogenesis in glioblastomas down regulates BACE1 while increasing ADAM10 maturation

A natural triterpene which stimulates wound healing induces cell cycle arrest and apoptosis in breast cancer cells (IC50 = 5.9 &microM for MCF-7 cells) blocks angiogenesis in glioblastomas down regulates BACE1 while increasing ADAM10 maturation

The main saponin constituent of C. asiatica that has been shown to improve wound healing including increasing collagen synthesis and elevating antioxidant levels in various normal and diabetic wound models.

The main saponin constituent of C. asiatica that has been shown to improve wound healing including increasing collagen synthesis and elevating antioxidant levels in various normal and diabetic wound models.

The main saponin constituent of C. asiatica that has been shown to improve wound healing including increasing collagen synthesis and elevating antioxidant levels in various normal and diabetic wound models.

An asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates demonstrates therapeutic activity in experimental models of organophosphate poisoning.