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17589-10A potent, selective inhibitor of ATR (IC<sub>50</sub> = 5 nM) inhibits the growth of LoVo colorectal adenocarcinoma cells in vitro and significantly reduces the growth of LoVo xenografts in mice.
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17589-25A potent, selective inhibitor of ATR (IC<sub>50</sub> = 5 nM) inhibits the growth of LoVo colorectal adenocarcinoma cells in vitro and significantly reduces the growth of LoVo xenografts in mice.
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17589-5A potent, selective inhibitor of ATR (IC<sub>50</sub> = 5 nM) inhibits the growth of LoVo colorectal adenocarcinoma cells in vitro and significantly reduces the growth of LoVo xenografts in mice.
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17994-10AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC<sub>50</sub>s = 15-17 nM) that spares the wild-type form of the receptor (IC<sub>50</sub> =
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17994-25AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC<sub>50</sub>s = 15-17 nM) that spares the wild-type form of the receptor (IC<sub>50</sub> =
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17994-5AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC<sub>50</sub>s = 15-17 nM) that spares the wild-type form of the receptor (IC<sub>50</sub> =
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17994-50AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC<sub>50</sub>s = 15-17 nM) that spares the wild-type form of the receptor (IC<sub>50</sub> =
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15336-1A quinazilinone that inhibits several Raf kinases, including B-Raf, B-RafV600E, and c-Raf-1 (IC<sub>50</sub>s = 105, 34, and 29 nM in vitro) inhibits anchorage-dependent and -independent growth, induces cell cycle arrest, and causes apoptosis in