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16876-10A PARP inhibitor (IC<sub>50</sub> = 5 nM) with low affinity for the P-glycoprotein drug efflux transporter induces a loss of p53 binding protein 1 expression in mice with KB1P tumors at 100 mg/kg.
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16876-25A PARP inhibitor (IC<sub>50</sub> = 5 nM) with low affinity for the P-glycoprotein drug efflux transporter induces a loss of p53 binding protein 1 expression in mice with KB1P tumors at 100 mg/kg.
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16876-5A PARP inhibitor (IC<sub>50</sub> = 5 nM) with low affinity for the P-glycoprotein drug efflux transporter induces a loss of p53 binding protein 1 expression in mice with KB1P tumors at 100 mg/kg.
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16728-1A GSK3&beta inhibitor (Ki = 4.9 nM) that crosses the blood brain barrier and inhibits tau phosphorylation (IC<sub>50</sub> = 76 nM in vitro) stabilizes &beta-catenin and increases bone mass (via Wnt activation) in rats after a two-week treatment
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16728-10A GSK3&beta inhibitor (Ki = 4.9 nM) that crosses the blood brain barrier and inhibits tau phosphorylation (IC<sub>50</sub> = 76 nM in vitro) stabilizes &beta-catenin and increases bone mass (via Wnt activation) in rats after a two-week treatment
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16728-5A GSK3&beta inhibitor (Ki = 4.9 nM) that crosses the blood brain barrier and inhibits tau phosphorylation (IC<sub>50</sub> = 76 nM in vitro) stabilizes &beta-catenin and increases bone mass (via Wnt activation) in rats after a two-week treatment
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17741-1CAS Number: 883986-34-3 Molecular Formula: C<sub>24</sub>H<sub>25</sub>N<sub>5</sub>O<sub>4 </sub> Formula Weight: 447.5
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17741-10CAS Number: 883986-34-3 Molecular Formula: C<sub>24</sub>H<sub>25</sub>N<sub>5</sub>O<sub>4 </sub> Formula Weight: 447.5
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17741-25CAS Number: 883986-34-3 Molecular Formula: C<sub>24</sub>H<sub>25</sub>N<sub>5</sub>O<sub>4 </sub> Formula Weight: 447.5
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17741-5CAS Number: 883986-34-3 Molecular Formula: C<sub>24</sub>H<sub>25</sub>N<sub>5</sub>O<sub>4 </sub> Formula Weight: 447.5
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19912-1A selective inhibitor of MCT1 (Ki = 1.6 nM), killing tumor cells that are reliant on glycolysis by blocking lactate transport increases intratumor lactate levels and decreases tumor growth in mice bearing SCLC xenografts.
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19912-10A selective inhibitor of MCT1 (Ki = 1.6 nM), killing tumor cells that are reliant on glycolysis by blocking lactate transport increases intratumor lactate levels and decreases tumor growth in mice bearing SCLC xenografts.