Life Science

Stabilizes HIF from degradation in the proteasome and increases endogenous production of erythropoietin by inhibiting HIF-1&alpha prolyl hydroxylase (IC₅₀ = 0.49 &microM) investigated in clinical trial for treatment of patients with

Stabilizes HIF from degradation in the proteasome and increases endogenous production of erythropoietin by inhibiting HIF-1&alpha prolyl hydroxylase (IC₅₀ = 0.49 &microM) investigated in clinical trial for treatment of patients with

The biological effects of the cysLTs, including LTC4, LTD4, and LTE4 are transduced mainly by a pair of 7-transmembrane receptors, CysLT1 and CysLT2. BAY u9773 is a non-selective antagonist of the CysLT receptors, having about the same

The biological effects of the cysLTs, including LTC4, LTD4, and LTE4 are transduced mainly by a pair of 7-transmembrane receptors, CysLT1 and CysLT2. BAY u9773 is a non-selective antagonist of the CysLT receptors, having about the same

The biological effects of the cysLTs, including LTC4, LTD4, and LTE4 are transduced mainly by a pair of 7-transmembrane receptors, CysLT1 and CysLT2. BAY u9773 is a non-selective antagonist of the CysLT receptors, having about the same

The biological effects of the cysLTs, including LTC4, LTD4, and LTE4 are transduced mainly by a pair of 7-transmembrane receptors, CysLT1 and CysLT2. BAY u9773 is a non-selective antagonist of the CysLT receptors, having about the same

The biological effects of PGD2 (Item No. 12010) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and DP2/CRTH2.

The biological effects of PGD2 (Item No. 12010) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and DP2/CRTH2.

The biological effects of PGD2 (Item No. 12010) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and DP2/CRTH2.

The biological effects of PGD2 (Item No. 12010) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and DP2/CRTH2.

A potent, selective CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 35 and &gt10,000 nM, respectively.

A potent, selective CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 35 and &gt10,000 nM, respectively.