Life Science

A natural indole alkaloid with demonstrated beneficial effects in cancer, obesity, inflammation, and many other conditions an AhR antagonist (Ki = 28 nM), activator of TRPV1 (EC₅₀ = 45 nM), and inhibitor of signaling through NF-&kappaB.

Goniothalesdiol, isolated from the bark of the Malaysian tree G. borneensis, is a tetrahydrofuran compound known to have significant cytotoxic effects against P388 mouse leukemia cells and pesticidal activities.

Goniothalesdiol, isolated from the bark of the Malaysian tree G. borneensis, is a tetrahydrofuran compound known to have significant cytotoxic effects against P388 mouse leukemia cells and pesticidal activities.

Goniothalesdiol, isolated from the bark of the Malaysian tree G. borneensis, is a tetrahydrofuran compound known to have significant cytotoxic effects against P388 mouse leukemia cells and pesticidal activities.

Displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains binds BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.

Displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains binds BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.

Displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains binds BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.

Displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains binds BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.

Potent, selective and non-competitive NMDA receptor antagonist (Ki = 30.5 nM) acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux.

Potent, selective and non-competitive NMDA receptor antagonist (Ki = 30.5 nM) acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux.

An inactive enantiomer of nutlin-3 that may serve as a useful control for non-MDM2 related cellular activities also called enantiomer b based on the elution pattern during chiral separation of (&plusmn)-nutlin-3.

An inactive enantiomer of nutlin-3 that may serve as a useful control for non-MDM2 related cellular activities also called enantiomer b based on the elution pattern during chiral separation of (&plusmn)-nutlin-3.