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10012424-25A potent, selective full agonist for BLT2 with an EC50 value of 20 nM activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM) dose dependently increases intracellular calcium stores and induces ERK phosphorylation in CHO
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10012424-5A potent, selective full agonist for BLT2 with an EC50 value of 20 nM activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM) dose dependently increases intracellular calcium stores and induces ERK phosphorylation in CHO
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10012424-50A potent, selective full agonist for BLT2 with an EC50 value of 20 nM activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM) dose dependently increases intracellular calcium stores and induces ERK phosphorylation in CHO
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10012682-1A novel inhibitor of HIF-1a accumulation and gene transcriptional activity inhibits HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM in human Hep3b and AGS cells, respectively.
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10012682-10A novel inhibitor of HIF-1a accumulation and gene transcriptional activity inhibits HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM in human Hep3b and AGS cells, respectively.
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10012682-25A novel inhibitor of HIF-1a accumulation and gene transcriptional activity inhibits HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM in human Hep3b and AGS cells, respectively.
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10012682-5A novel inhibitor of HIF-1a accumulation and gene transcriptional activity inhibits HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM in human Hep3b and AGS cells, respectively.
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13143-1A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41) increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat.
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13143-10A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41) increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat.
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13143-25A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41) increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat.
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13143-5A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41) increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat.
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13164-1A dual inhibitor of mPGES-1 (IC<sub>50 </sub>= 1.3 &muM) and 5-LO (IC<sub>50</sub> = 1.0 &muM) effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays.