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10012536-5A selective PPARd agonist that acts as a partial agonist (EC50 = 53 nM) in transactivation assays and as a full agonist (EC50 = 30 nM) in the oxidation of free fatty acid increases HDL levels, decreases LDL and TG levels, and improves insulin
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13207-1A potent PLD2 inhibitor, both in vitro (IC<sub>50</sub> = 140 nM) and in cells (IC<sub>50</sub> = 110 nM) also effective as a PLD1 inhibitor at higher concentrations (IC<sub>50</sub> = 5.1 &muM in vitro, 1.
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13207-10A potent PLD2 inhibitor, both in vitro (IC<sub>50</sub> = 140 nM) and in cells (IC<sub>50</sub> = 110 nM) also effective as a PLD1 inhibitor at higher concentrations (IC<sub>50</sub> = 5.1 &muM in vitro, 1.
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13207-25A potent PLD2 inhibitor, both in vitro (IC<sub>50</sub> = 140 nM) and in cells (IC<sub>50</sub> = 110 nM) also effective as a PLD1 inhibitor at higher concentrations (IC<sub>50</sub> = 5.1 &muM in vitro, 1.
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13207-5A potent PLD2 inhibitor, both in vitro (IC<sub>50</sub> = 140 nM) and in cells (IC<sub>50</sub> = 110 nM) also effective as a PLD1 inhibitor at higher concentrations (IC<sub>50</sub> = 5.1 &muM in vitro, 1.
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10012553-1A potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 10 nM R enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 7.3 nM.
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10012553-10A potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 10 nM R enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 7.3 nM.
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10012553-5A potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 10 nM R enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 7.3 nM.
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10012539-1A potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 40 nM.
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10012539-10A potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 40 nM.
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10012539-5A potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 40 nM.
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13281-1A very potent agonist of EP4, binding with a Ki value of 1.2 nM does not bind EP1, EP2, EP3, DP, FP, IP, or TP receptors.