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18867-1A potent, selective inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM) bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model decreases hepatic necrosis and apoptosis
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18867-10A potent, selective inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM) bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model decreases hepatic necrosis and apoptosis
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18867-5A potent, selective inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM) bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model decreases hepatic necrosis and apoptosis
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10787-10Inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC3 prostate cancer cells with an IC50 value of 9.8 µM.
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10787-25Inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC3 prostate cancer cells with an IC50 value of 9.8 µM.
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10787-5Inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC3 prostate cancer cells with an IC50 value of 9.8 µM.
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10787-50Inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC3 prostate cancer cells with an IC50 value of 9.8 µM.
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10010350-10A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.
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10010350-25A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.
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10010350-5A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.
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10010350-50A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.
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15075-10An inhibitor of SRE activation in PC3 cells (IC<sub>50</sub> = 6.4 &muM), with 87% inhibition of SRE activation achieved at 100 &muM inhibits PC3 cell migration (IC<sub>50</sub> = 4.