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18194-50An ATP-competitive inhibitor of Akt2 (IC<sub>50</sub> = 6 nM) blocks the phosphorylation of Akt targets, inhibits proliferation of multiple tumor cell lines in vitro, and prevents the growth of human tumor xenografts in mice.
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15552-10A potent inhibitor of Aurora kinases (IC<sub>50</sub>s = 15, 25 and 19 nM for Aurora A, B, and C, respectively) also inhibits FLT3 as well as the constitutively active FLT3-ITD form (IC<sub>50</sub>s = 1.2 and 4.
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15552-5A potent inhibitor of Aurora kinases (IC<sub>50</sub>s = 15, 25 and 19 nM for Aurora A, B, and C, respectively) also inhibits FLT3 as well as the constitutively active FLT3-ITD form (IC<sub>50</sub>s = 1.2 and 4.
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15552-50A potent inhibitor of Aurora kinases (IC<sub>50</sub>s = 15, 25 and 19 nM for Aurora A, B, and C, respectively) also inhibits FLT3 as well as the constitutively active FLT3-ITD form (IC<sub>50</sub>s = 1.2 and 4.
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18761-1CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC<sub>50 </sub>= 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.
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18761-10CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC<sub>50 </sub>= 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.
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18761-5CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC<sub>50 </sub>= 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.
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17870-1A fluorescent molecular rotor characterized by low background fluorescence, low fluorescence anisotropy, and good water solubility its large hydrophobic structures allow it to associate in a non-covalent manner with hydrophobic pockets in proteins
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17870-10A fluorescent molecular rotor characterized by low background fluorescence, low fluorescence anisotropy, and good water solubility its large hydrophobic structures allow it to associate in a non-covalent manner with hydrophobic pockets in proteins
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17870-5A fluorescent molecular rotor characterized by low background fluorescence, low fluorescence anisotropy, and good water solubility its large hydrophobic structures allow it to associate in a non-covalent manner with hydrophobic pockets in proteins
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19062-1A selective RAR&gamma agonist (Kds = 150, 1,500, and 2,750 nM for RAR&gamma, RAR&beta, and RAR&alpha receptors, respectively) demonstrates transcriptional activity at RAR&gamma with an AC<sub>50</sub> value of 1.8 nM.
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19062-10A selective RAR&gamma agonist (Kds = 150, 1,500, and 2,750 nM for RAR&gamma, RAR&beta, and RAR&alpha receptors, respectively) demonstrates transcriptional activity at RAR&gamma with an AC<sub>50</sub> value of 1.8 nM.