Life Science

A phytoestrogen that competitively (vs. 17&beta-estradiol) binds the estrogen receptors ER&alpha (IC50 = 11 nM) and ER&beta (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells a weak antagonist of pregnane X receptor

A phytoestrogen that competitively (vs. 17&beta-estradiol) binds the estrogen receptors ER&alpha (IC50 = 11 nM) and ER&beta (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells a weak antagonist of pregnane X receptor

The COX (human) Inhibitor Screening Assay Kit directly measures PGF2&alpha by SnCl2 reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using a broadly specific antiserum that binds to all the

The COX Colorimetric Inhibitor Screening Assay measures the peroxidase component of cyclooxygenases. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized TMPD at 590 nm.

The COX (ovine/human) Inhibitor Screening Assay directly measures PGF2&alpha produced by SnCl2 reduction of COX-derived PGH2. The prostanoid product is quantified via ELISA using a broadly specific antibody that binds to all the major PG compounds.

The COX Activity Assay utilizes the peroxidase component of cyclooxygenases. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized TMPD at 590 nm.

The COX Colorimetric Inhibitor Screening Assay measures the peroxidase component of cyclooxygenases. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized N,N,N&#39,N&#39-tetramethyl-p-phenylenediamine (TMPD)

Cayman&rsquos COX Fluorescent Activity Assay provides a convenient fluorescence-based method for detecting COX-1 or COX-2 activity in both crude (cell lysates/tissue homogenates) and purified enzyme preparations. The assay utilizes the peroxidase

Cayman&rsquos COX Fluorescent Inhibitor Screening Assay provides a convenient fluorescence-based method for screening ovine COX-1 and human recombinant COX-2 for isozyme-specific inhibitors. The assay utilizes the peroxidase component of COXs.

The Cayman COX Inhibitor Pack contains a combination of frequently used cyclooxygenase (COX) inhibitors. Each kit contains aspirin, the archetype nonselective, irreversible COX inhibitor.

Cyclooxygenase (COX, also called Prostaglandin H Synthase or PGHS) is a bifunctional enzyme that converts arachidonic acid to a hydroperoxy endoperoxide (PGG₂) and reduces the endoperoxide to the corresponding alcohol (PGH₂),

COX-1 and COX-2 catalyze the production of the PG and TX precursor PGH2. COX-2 is primarily responsible for the biosynthesis of PGs under acute inflammatory conditions.