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18821-50A second messenger that is biosynthesized from GTP by guanylate cyclases activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation,
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14748-10A stable analog of PFT-&alpha, formed by the condensation of PFT-&alpha in solution inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC<sub>50</sub> = 23, 77, and 103 &muM, respectively) induces autophagy in HCT116 cells
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14748-25A stable analog of PFT-&alpha, formed by the condensation of PFT-&alpha in solution inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC<sub>50</sub> = 23, 77, and 103 &muM, respectively) induces autophagy in HCT116 cells
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14748-5A stable analog of PFT-&alpha, formed by the condensation of PFT-&alpha in solution inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC<sub>50</sub> = 23, 77, and 103 &muM, respectively) induces autophagy in HCT116 cells
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14748-50A stable analog of PFT-&alpha, formed by the condensation of PFT-&alpha in solution inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC<sub>50</sub> = 23, 77, and 103 &muM, respectively) induces autophagy in HCT116 cells
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16861-10An active metabolite of proguanil, produced by CYP2C19 an inhibitor of dihydrofolate reductase (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
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16861-25An active metabolite of proguanil, produced by CYP2C19 an inhibitor of dihydrofolate reductase (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
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16861-5An active metabolite of proguanil, produced by CYP2C19 an inhibitor of dihydrofolate reductase (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
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16861-50An active metabolite of proguanil, produced by CYP2C19 an inhibitor of dihydrofolate reductase (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
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14126-1An inhibitor of protein synthesis in eukaryotes (IC<sub>50</sub> = 5-50 &muM) that functions by interfering with translational elongation can either induce or inhibit apoptosis depending on cell type.
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14126-100An inhibitor of protein synthesis in eukaryotes (IC<sub>50</sub> = 5-50 &muM) that functions by interfering with translational elongation can either induce or inhibit apoptosis depending on cell type.
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11321-1A natural steroidal alkaloid that inhibits signaling through the Hh pathway at the level of the pathway activator Smo inhibits Hh-dependent expression of Pax7 with an IC50 value of 24 nM has potential applications in the treatment of cancer.