Life Science

A natural steroidal alkaloid that inhibits signaling through the Hh pathway at the level of the pathway activator Smo inhibits Hh-dependent expression of Pax7 with an IC50 value of 24 nM has potential applications in the treatment of cancer.

A natural steroidal alkaloid that inhibits signaling through the Hh pathway at the level of the pathway activator Smo inhibits Hh-dependent expression of Pax7 with an IC50 value of 24 nM has potential applications in the treatment of cancer.

This mixture contains all of the major UV-absorbing cyclopentenone prostaglandins and their precursors. Contents: 100 &microg of each compound Prostaglandin A2 (Item No.

A nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.

A nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.

A nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.

A nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.

A mycotoxin that specifically and reversibly inhibits sarco-endoplasmic reticulum Ca2+-ATPases (SERCA IC50 = 0.6 &muM) effectively inhibits SERCA in intact tissue, in smooth muscle and endothelium, as well as in isolated cells.

A mycotoxin that specifically and reversibly inhibits sarco-endoplasmic reticulum Ca2+-ATPases (SERCA IC50 = 0.6 &muM) effectively inhibits SERCA in intact tissue, in smooth muscle and endothelium, as well as in isolated cells.

A mycotoxin that specifically and reversibly inhibits sarco-endoplasmic reticulum Ca2+-ATPases (SERCA IC50 = 0.6 &muM) effectively inhibits SERCA in intact tissue, in smooth muscle and endothelium, as well as in isolated cells.

An immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC₅₀ = 5 nM), which interferes with the nuclear import of NFAT, a transcription factor involved in T cell activation used

An immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC₅₀ = 5 nM), which interferes with the nuclear import of NFAT, a transcription factor involved in T cell activation used