Life Science

An orally available inhibitor of microtubule polymerization (IC₅₀ = ~3 &microM) that blocks cell cycling at the G2-M phase, which leads to cell death cytotoxic to a range of cancer cell lines (IC₅₀s = 9-101 nM) and

A nucleoside analog that differs from cytosine by the presence of a hydroxyl group at the 2&rsquo position of the sugar residue triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases &alpha and &beta (Kis = 4

A nucleoside analog that differs from cytosine by the presence of a hydroxyl group at the 2&rsquo position of the sugar residue triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases &alpha and &beta (Kis = 4

A nucleoside analog that differs from cytosine by the presence of a hydroxyl group at the 2&rsquo position of the sugar residue triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases &alpha and &beta (Kis = 4

A nucleoside analog that differs from cytosine by the presence of a hydroxyl group at the 2&rsquo position of the sugar residue triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases &alpha and &beta (Kis = 4

A pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions, including RNA synthesis, the formation of PC, and sialylation.

A pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions, including RNA synthesis, the formation of PC, and sialylation.

A pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions, including RNA synthesis, the formation of PC, and sialylation.

A pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions, including RNA synthesis, the formation of PC, and sialylation.

Azacytidine is a cytidine analog that is incorporated into DNA, inhibiting DNA methyltransferase (DNMT) activity and preventing DNA repair. This demethylating agent is clinically used to treat myelodysplastic syndromes and potentiates the effects of

Azacytidine is a cytidine analog that is incorporated into DNA, inhibiting DNA methyltransferase (DNMT) activity and preventing DNA repair. This demethylating agent is clinically used to treat myelodysplastic syndromes and potentiates the effects of

Azacytidine is a cytidine analog that is incorporated into DNA, inhibiting DNA methyltransferase (DNMT) activity and preventing DNA repair. This demethylating agent is clinically used to treat myelodysplastic syndromes and potentiates the effects of