Biologically Active Small Molecules

12(R)-HEPE is a monohydroxy fatty acid synthesized from EPA by the eggs of the sea urchin, S. purpuratus. The biological activity of 12(R)-HEPE has not been extensively documented, but may be similar to that of 12(R)-HETE.

12(R)-HEPE is a monohydroxy fatty acid synthesized from EPA by the eggs of the sea urchin, S. purpuratus. The biological activity of 12(R)-HEPE has not been extensively documented, but may be similar to that of 12(R)-HETE.

A proinflammatory monohydroxy oxidation product of arachidonic acid formed by 12(R)-LO.

A proinflammatory monohydroxy oxidation product of arachidonic acid formed by 12(R)-LO.

A proinflammatory monohydroxy oxidation product of arachidonic acid formed by 12(R)-LO.

12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway.

12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway.

12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway.

The predominant LO product of arachidonic acid formed in mammalian platelets enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 &microM.

A form of 12(S)-HETE with an &omega-terminal alkyne for use in click chemistry reactions.

A form of 12(S)-HETE with an &omega-terminal alkyne for use in click chemistry reactions.

A form of 12(S)-HETE with an &omega-terminal alkyne for use in click chemistry reactions.