Biologically Active Small Molecules

An aspirin-triggered lipoxin that inhibits LTB4-induced chemotaxis, adherence, and transmigration of the neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.

An aspirin-triggered lipoxin that inhibits LTB4-induced chemotaxis, adherence, and transmigration of the neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.

An aspirin-triggered lipoxin that inhibits LTB4-induced chemotaxis, adherence, and transmigration of the neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.

A potent and selective CRTH2/DP2 receptor agonist, that is equipotent with PGD2 at this receptor.

A potent and selective CRTH2/DP2 receptor agonist, that is equipotent with PGD2 at this receptor.

15(R)-PGE1 is the &ldquounnatural&rdquo C-15 stereoisomer of PGE1. It is essentially inactive biologically when compared to PGE1. It is a non-competitive inhibitor of 15-hydroxy PGDH with an IC₅₀ of 189 &microM.

15(R)-PGE1 is the &ldquounnatural&rdquo C-15 stereoisomer of PGE1. It is essentially inactive biologically when compared to PGE1. It is a non-competitive inhibitor of 15-hydroxy PGDH with an IC₅₀ of 189 &microM.

15(R)-PGE1 is the &ldquounnatural&rdquo C-15 stereoisomer of PGE1. It is essentially inactive biologically when compared to PGE1. It is a non-competitive inhibitor of 15-hydroxy PGDH with an IC₅₀ of 189 &microM.

15(R)-PGE2 is the C-15 epimer of the naturally occurring 15(S)-PGE2. 15(R)-PGE2 is much less potent than the natural stereoisomer in most biological assays.

15(R)-PGE2 is the C-15 epimer of the naturally occurring 15(S)-PGE2. 15(R)-PGE2 is much less potent than the natural stereoisomer in most biological assays.

15(R)-PGE2 is the C-15 epimer of the naturally occurring 15(S)-PGE2. 15(R)-PGE2 is much less potent than the natural stereoisomer in most biological assays.

15(R)-PGF2&alpha is the C-15 epimer of the naturally occurring mammalian autacoid PGF2&alpha. It has only 25% of the potency of PGF2&alpha in hamster antifertility studies, which may be due to reduced affinity for FP receptors.