Biologically Active Small Molecules

An ER&beta Selective agonist exhibits 70-fold higher relative binding affinity for ER&beta versus ER&alpha.

An ER&beta Selective agonist exhibits 70-fold higher relative binding affinity for ER&beta versus ER&alpha.

An ER&beta Selective agonist exhibits 70-fold higher relative binding affinity for ER&beta versus ER&alpha.

A proapoptoic compound with selectivity for cancer cells induces apoptosis in vitro in various cancer cell lines (IC50 = 0.89-2.69 &microM).

A proapoptoic compound with selectivity for cancer cells induces apoptosis in vitro in various cancer cell lines (IC50 = 0.89-2.69 &microM).

A proapoptoic compound with selectivity for cancer cells induces apoptosis in vitro in various cancer cell lines (IC50 = 0.89-2.69 &microM).

Both inhibits and inactivates, at 100 &microM, certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2).

Both inhibits and inactivates, at 100 &microM, certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2).

Both inhibits and inactivates, at 100 &microM, certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2).

Fluprostenol is a well-studied, potent analog of PGF2&alpha acting primarily through the FP receptor. &beta-Oxidation of fluprostenol yields 2,3-dinor fluprostenol.

Fluprostenol is a well-studied, potent analog of PGF2&alpha acting primarily through the FP receptor. &beta-Oxidation of fluprostenol yields 2,3-dinor fluprostenol.

Fluprostenol is a well-studied, potent analog of PGF2&alpha acting primarily through the FP receptor. &beta-Oxidation of fluprostenol yields 2,3-dinor fluprostenol.