Biologically Active Small Molecules

A pyrazine derivative that is used as a flavoring agent in the food and tobacco industry has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC₅₀ = ~1.25 mM).

A pyrazine derivative that is used as a flavoring agent in the food and tobacco industry has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC₅₀ = ~1.25 mM).

A pyrazine derivative that is used as a flavoring agent in the food and tobacco industry has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC₅₀ = ~1.25 mM).

A fluorescent indicator of peroxynitrite formation neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH.

A fluorescent indicator of peroxynitrite formation neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH.

A fluorescent indicator of peroxynitrite formation neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH.

A fluorescent indicator of peroxynitrite formation neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH.

A novel CYP450 metabolite of 2-AG in the kidney acts as a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 &microM.

A novel CYP450 metabolite of 2-AG in the kidney acts as a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 &microM.

A novel CYP450 metabolite of 2-AG in the kidney acts as a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 &microM.

A synthetic intermediate useful for pharmaceutical synthesis.

A synthetic intermediate useful for pharmaceutical synthesis.