Biologically Active Small Molecules

The E isomer of the pyrophosphonate form of HDMAPP potently stimulates the synthesis of TNF-&alpha by &gamma&delta-T lymphocytes with an IC₅₀ valueof 0.91 nM also significantly increases the number of circulating &gamma&delta-T

The E isomer of the pyrophosphonate form of HDMAPP potently stimulates the synthesis of TNF-&alpha by &gamma&delta-T lymphocytes with an IC₅₀ valueof 0.91 nM also significantly increases the number of circulating &gamma&delta-T

A bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.

A bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.

A bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.

A bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.

An active metabolite of tamoxifen that is formed by the action of CYP2D6 in human liver inhibits MCF-7 and MDA-MB 231 cell proliferation with IC₅₀ values of 27 and 18 &microM, respectively stimulates LC3 lipidation and formation of

An active metabolite of tamoxifen that is formed by the action of CYP2D6 in human liver inhibits MCF-7 and MDA-MB 231 cell proliferation with IC₅₀ values of 27 and 18 &microM, respectively stimulates LC3 lipidation and formation of

An active metabolite of tamoxifen that is formed by the action of CYP2D6 in human liver inhibits MCF-7 and MDA-MB 231 cell proliferation with IC₅₀ values of 27 and 18 &microM, respectively stimulates LC3 lipidation and formation of

An active metabolite of tamoxifen that is formed by the action of CYP2D6 in human liver inhibits MCF-7 and MDA-MB 231 cell proliferation with IC₅₀ values of 27 and 18 &microM, respectively stimulates LC3 lipidation and formation of

A pyroglutamylated form of apelin-13, in that the N-terminal glutamine residue is cyclized to pyroglutamic acid a potent APJ receptor agonist (EC₅₀ = 0.30 nM) the major apelin isoform in the plasma of healthy human subjects.

An analog of AEA in which the alcohol of the ethanolamide group has been replaced with a fluorine atom, which increases the binding affinity and selectivity for the CB1 receptor (Ki = 5.7 nM in rat brain) in vivo activity is enhanced much less than