Biologically Active Small Molecules

A derivative of 2-DG that is produced in mammalian cells by the action of hexokinase accumulation of 2-DG6P in cells can inhibit glycolysis, leading to cell death.

A derivative of 2-DG that is produced in mammalian cells by the action of hexokinase accumulation of 2-DG6P in cells can inhibit glycolysis, leading to cell death.

A nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents.

A nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents.

A nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents.

2-fluoro Palmitic acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase with an IC₅₀ value of 0.2 mM.

2-fluoro Palmitic acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase with an IC₅₀ value of 0.2 mM.

2-fluoro Palmitic acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase with an IC₅₀ value of 0.2 mM.

2-fluoro Palmitic acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase with an IC₅₀ value of 0.2 mM.

A potent and selective agonist of the proteinase-activated receptor, PAR2 (pD2 = 7.0) produces a concentration-dependent relaxation of arteries previously contracted with &alpha1 adrenergic receptor agonists.

A potent inhibitor of enkephalin convertase (Ki = 8.8 nM) that is functional in vivo can also inhibit other carboxypeptidases, including TAFI.

A synthetic analog of curcumin that activates enzymes which catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway increases NQO1 activity, glutathione reductase activity, and total glutathione levels in vitro at 0.6 &ndash 0.