Biologically Active Small Molecules

A cysteine sulfoxide constituent of garlic that exhibits anti-cancer, anti-microbial, anti-hypertensive, cardioprotective, and anti-oxidant activities inhibits squalene monooxygenase (IC₅₀ = 120 &muM), a rate-limiting step in the

A selective agonist of GABAB (IC₅₀ = 200 nM) causes skeletal muscle relaxation and blocks spasticity.

A selective agonist of GABAB (IC₅₀ = 200 nM) causes skeletal muscle relaxation and blocks spasticity.

A selective agonist of GABAB (IC₅₀ = 200 nM) causes skeletal muscle relaxation and blocks spasticity.

A selective agonist of GABAB (IC₅₀ = 200 nM) causes skeletal muscle relaxation and blocks spasticity.

A selective cell-permeable inhibitor of non-muscle myosin II ATPases, inhibiting Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.

A selective cell-permeable inhibitor of non-muscle myosin II ATPases, inhibiting Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.

A selective cell-permeable inhibitor of non-muscle myosin II ATPases, inhibiting Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.

A selective cell-permeable inhibitor of non-muscle myosin II ATPases, inhibiting Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.

A stable inhibitor of FAS that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.

A stable inhibitor of FAS that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.

A stable inhibitor of FAS that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.