Biologically Active Small Molecules

An analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis inhibits human keratinocyte proliferation and is beneficial in treating psoriasis blocks the proliferation while inducing

A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXR&alpha and LXR&beta nuclear receptors with slightly reduced potency (EC50 = 7 and 4 &muM, respectively) compared to the natural isomer (EC50 = 4 and 3 &muM,

A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXR&alpha and LXR&beta nuclear receptors with slightly reduced potency (EC50 = 7 and 4 &muM, respectively) compared to the natural isomer (EC50 = 4 and 3 &muM,

A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXR&alpha and LXR&beta nuclear receptors with slightly reduced potency (EC50 = 7 and 4 &muM, respectively) compared to the natural isomer (EC50 = 4 and 3 &muM,

A side-chain substituted oxysterol that has important roles in cholesterol homeostasis potently activates LXR&alpha and LXR&beta nuclear receptors (EC50 = 4 and 3 &muM, respectively), causing upregulation of cholesterol-lowering genes.

A side-chain substituted oxysterol that has important roles in cholesterol homeostasis potently activates LXR&alpha and LXR&beta nuclear receptors (EC50 = 4 and 3 &muM, respectively), causing upregulation of cholesterol-lowering genes.

A side-chain substituted oxysterol that has important roles in cholesterol homeostasis potently activates LXR&alpha and LXR&beta nuclear receptors (EC50 = 4 and 3 &muM, respectively), causing upregulation of cholesterol-lowering genes.

An immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic

An immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic

An immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic

An immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic

A naturally occurring plant sterol that inhibits the absorption of dietary and endogenously produced cholesterol from the small intestine, reducing blood cholesterol concentrations at 0.1 - 100 &muM dose dependently induces adipogenesis and