Biologically Active Small Molecules

4-(1-piperazinyl)-1H-Indole (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.

A potent inhibitor of FAAH, with an IC₅₀ of 9.1 nM also inhibits MAGL at ~1,000-fold higher concentration (IC₅₀ = 7.9 &muM).

A potent inhibitor of FAAH, with an IC₅₀ of 9.1 nM also inhibits MAGL at ~1,000-fold higher concentration (IC₅₀ = 7.9 &muM).

A potent inhibitor of FAAH, with an IC₅₀ of 9.1 nM also inhibits MAGL at ~1,000-fold higher concentration (IC₅₀ = 7.9 &muM).

A potent inhibitor of FAAH, with an IC₅₀ of 9.1 nM also inhibits MAGL at ~1,000-fold higher concentration (IC₅₀ = 7.9 &muM).

A synthetic intermediate for pharmaceutical synthesis.

A synthetic intermediate for pharmaceutical synthesis.

A synthetic intermediate for pharmaceutical synthesis.

A synthetic intermediate useful for pharmaceutical synthesis.

A synthetic intermediate useful for pharmaceutical synthesis.

A synthetic intermediate useful for pharmaceutical synthesis.

An inhibitor of PARP (IC₅₀ = 180 nM) blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of &gamma-radiation, although it is not cytotoxic in the absence of radiation.